| 产品: | p50 Dynamitin 抗体 |
| 货号: | AF0232 |
| 描述: | Rabbit polyclonal antibody to p50 Dynamitin |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 50kDa; 44kD(Calculated). |
| 蛋白号: | Q13561 |
| RRID: | AB_2833407 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0232, RRID:AB_2833407.
展开/折叠
50 kD dynein associated polypeptide; 50 kDa dynein associated polypeptide; 50 kDa dynein-associated polypeptide; DCTN-50; DCTN2; DCTN2_HUMAN; DCTN50; dynactin 2 (p50); dynactin 2; dynactin complex 50 kD subunit; Dynactin complex 50 kDa subunit; Dynactin subunit 2; DYNAMITIN; p50 dynamitin; RBP50;
抗原和靶标
- Q13561 DCTN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13561 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| Y6 | Phosphorylation | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| K65 | Methylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| R72 | Methylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| Y86 | Phosphorylation | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| T115 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| T134 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| T198 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| T232 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K308 | Acetylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| T315 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot |
研究背景
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Membrane>Peripheral membrane protein.
Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By similarity). Interacts with DYNAP. Interacts with ECPAS. Interacts with MAPRE1.
Belongs to the dynactin subunit 2 family.
研究领域
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
限制条款
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