| 产品: | VAV2 抗体 |
| 货号: | AF4746 |
| 描述: | Rabbit polyclonal antibody to VAV2 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Horse, Chicken, Xenopus |
| 分子量: | 101kDa; 101kD(Calculated). |
| 蛋白号: | P52735 |
| RRID: | AB_2844604 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4746, RRID:AB_2844604.
展开/折叠
Guanine nucleotide exchange factor VAV2; Oncogene VAV2; Protein vav 2; VAV 2; Vav 2 oncogene; VAV-2; VAV2; VAV2 oncogene; VAV2_HUMAN;
抗原和靶标
- P52735 VAV2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P52735 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S91 | Phosphorylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| Y142 | Phosphorylation | P06239 (LCK) , P00533 (EGFR) | Uniprot |
| Y159 | Phosphorylation | P06239 (LCK) , P00533 (EGFR) | Uniprot |
| Y172 | Phosphorylation | P06239 (LCK) , P00533 (EGFR) | Uniprot |
| K212 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| K413 | Ubiquitination | Uniprot | |
| Y426 | Phosphorylation | Uniprot | |
| K515 | Acetylation | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| T575 | Phosphorylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| S639 | Phosphorylation | Uniprot | |
| S663 | Phosphorylation | Uniprot | |
| S692 | Phosphorylation | Uniprot | |
| K718 | Ubiquitination | Uniprot | |
| K757 | Ubiquitination | Uniprot | |
| S778 | Phosphorylation | Uniprot | |
| S779 | Phosphorylation | Uniprot | |
| S781 | Phosphorylation | Uniprot | |
| S836 | Phosphorylation | Uniprot |
研究背景
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Phosphorylated on tyrosine residues in response to FGR activation.
Widely expressed.
Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > B cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc epsilon RI signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
限制条款
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