Acetyl-SOD2/MnSOD (Lys122) Antibody - #AF4360
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| 产品: | 乙酰化SOD2/MnSOD (Lys122) 抗体 |
| 货号: | AF4360 |
| 描述: | Rabbit polyclonal antibody to Acetyl-SOD2/MnSOD (Lys122) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Xenopus |
| 分子量: | 22kDa; 25kD(Calculated). |
| 蛋白号: | P04179 |
| RRID: | AB_2844622 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4360, RRID:AB_2844622.
展开/折叠
Indophenoloxidase B; IPO B; IPOB; Manganese containing superoxide dismutase; Manganese SOD; Manganese superoxide dismutase; Mangano superoxide dismutase; Mn SOD; Mn superoxide dismutase; MNSOD; MVCD6; SOD 2; SOD2; SODM_HUMAN; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn], mitochondrial; Superoxide dismutase 2 mitochondrial;
抗原和靶标
- P04179 SODM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P04179 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K53 | Acetylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| K68 | Acetylation | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | P06493 (CDK1) , P11802 (CDK4) | Uniprot |
| K122 | Acetylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| K130 | Acetylation | Uniprot | |
| K130 | Methylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K132 | Acetylation | Uniprot | |
| K221 | Acetylation | Uniprot |
研究背景
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.
Mitochondrion matrix.
Homotetramer.
Belongs to the iron/manganese superoxide dismutase family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway - multiple species. (View pathway)
文献引用
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