| 产品: | TOB1 抗体 |
| 货号: | AF4739 |
| 描述: | Rabbit polyclonal antibody to TOB1 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Xenopus |
| 分子量: | 38kDa; 38kD(Calculated). |
| 蛋白号: | P50616 |
| RRID: | AB_2844738 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4739, RRID:AB_2844738.
展开/折叠
APRO 6; APRO6; MGC104792; MGC34446; PIG 49; PIG49; Proliferation inducing gene 49; Protein Tob1; RP23 244C22.1; TOB 1; Tob 1 protein; TOB; TOB1; Tob1 protein; Transducer of ERBB 2 1; Transducer of erbB 2; Transducer of ERBB2 1; Transducer of erbB2; Trob; TROB 1; TROB1;
抗原和靶标
- P50616 TOB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50616 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y40 | Phosphorylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| S152 | Phosphorylation | P45984 (MAPK9) , P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
| S154 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) , P45984 (MAPK9) | Uniprot |
| S164 | Phosphorylation | P45984 (MAPK9) , P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
| T204 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot |
研究背景
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
Phosphorylated on Ser and Thr residues.
Cytoplasm. Nucleus.
Note: Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
Ubiquitous.
Interacts with ERBB2. Interacts with CNOT7. Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay. Interacts with CNOT8. Interacts with CPEB4.
Belongs to the BTG family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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