| 产品: | MUNC-18a 抗体 |
| 货号: | AF4751 |
| 描述: | Rabbit polyclonal antibody to MUNC-18a |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 70kDa; 68kD(Calculated). |
| 蛋白号: | P61764 |
| RRID: | AB_2844746 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4751, RRID:AB_2844746.
展开/折叠
FLJ37475; Munc 18 1; Munc 18a; MUNC18 1; N-Sec1; Neuronal SEC1; NSec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; Rb sec1; RBSEC1; STXB1_HUMAN; STXBP1; Syntaxin binding protein 1; Syntaxin-binding protein 1; Unc 18 homolog; Unc 18A; Unc-18A; Unc18 1; UNC18; Unc18-1;
抗原和靶标
- P61764 STXB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P61764 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K7 | Ubiquitination | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| K321 | Methylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| T479 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| T489 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| Y531 | Phosphorylation | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot |
研究背景
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.
Brain and spinal cord. Highly enriched in axons.
Interacts with SYTL4 (By similarity). Interacts with STX1A. Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation. Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity).
Belongs to the STXBP/unc-18/SEC1 family.
研究领域
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
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