产品: | PLC beta 3 抗体 |
货号: | AF4754 |
描述: | Rabbit polyclonal antibody to PLC beta 3 |
应用: | WB |
反应: | Human, Mouse, Rat |
预测: | Pig, Bovine, Horse, Sheep, Dog |
分子量: | 139kDa; 139kD(Calculated). |
蛋白号: | Q01970 |
RRID: | AB_2844749 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4754, RRID:AB_2844749.
展开/折叠
1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase beta 3; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-3; Phospholipase C beta 3; Phospholipase C beta 3 (phosphatidylinositol specific); Phospholipase C-beta-3; PLC beta 3; PLC-beta-3; Plcb3; PLCB3_HUMAN;
抗原和靶标
- Q01970 PLCB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAPGSSGHLSGADSESQEENTQL
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q01970 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
A2 | Acetylation | Uniprot | |
S26 | Phosphorylation | Uniprot | |
K30 | Ubiquitination | Uniprot | |
K161 | Ubiquitination | Uniprot | |
K173 | Ubiquitination | Uniprot | |
K196 | Ubiquitination | Uniprot | |
S270 | Phosphorylation | Uniprot | |
Y279 | Phosphorylation | Uniprot | |
K424 | Ubiquitination | Uniprot | |
S474 | Phosphorylation | Uniprot | |
S480 | Phosphorylation | Uniprot | |
S490 | Phosphorylation | Uniprot | |
S495 | Phosphorylation | Uniprot | |
S537 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
Y548 | Phosphorylation | Uniprot | |
K572 | Acetylation | Uniprot | |
S632 | Phosphorylation | Uniprot | |
Y746 | Phosphorylation | Uniprot | |
K804 | Ubiquitination | Uniprot | |
S814 | Phosphorylation | Uniprot | |
Y847 | Phosphorylation | Uniprot | |
Y855 | Phosphorylation | Uniprot | |
S867 | Phosphorylation | Uniprot | |
S911 | Phosphorylation | Uniprot | |
S916 | Phosphorylation | Uniprot | |
T924 | Phosphorylation | Uniprot | |
T925 | Phosphorylation | Uniprot | |
S926 | Phosphorylation | Uniprot | |
S931 | Phosphorylation | Uniprot | |
S933 | Phosphorylation | Uniprot | |
S934 | Phosphorylation | Uniprot | |
K1029 | Ubiquitination | Uniprot | |
Y1031 | Phosphorylation | Uniprot | |
K1081 | Acetylation | Uniprot | |
S1105 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
S1107 | Phosphorylation | Uniprot | |
T1122 | Phosphorylation | Uniprot | |
T1130 | Phosphorylation | Uniprot | |
K1167 | Ubiquitination | Uniprot |
研究背景
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Membrane>Peripheral membrane protein.
Interacts with SHANK2 (By similarity). Interacts with LPAR2.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Parasitic > African trypanosomiasis.
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Nervous system > Long-term potentiation.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
· Organismal Systems > Nervous system > Glutamatergic synapse.
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Nervous system > Dopaminergic synapse.
· Organismal Systems > Nervous system > Long-term depression.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Melanogenesis.
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Endocrine system > Relaxin signaling pathway.
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
· Organismal Systems > Digestive system > Salivary secretion.
· Organismal Systems > Digestive system > Gastric acid secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
文献引用
Application: WB Species: Mouse Sample:
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