(1)
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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12079, RRID:AB_2844884.
展开/折叠
90K; 90K MAC 2 BP; Basement membrane autoantigen p105; BTBD17B; Galectin 3 binding protein; Galectin-3-binding protein; L3 antigen; Lectin galactoside binding soluble 3 binding protein; Lectin galactoside-binding soluble 3-binding protein; LG3BP_HUMAN; LGALS3BP; M2BP; Mac 2 binding protein; Mac 2 BP; Mac-2 BP; Mac-2-binding protein; Mac2 BP; MAC2BP; Serum protein 90K; TANGO10B; Transport and golgi organization 10 homolog B; Tumor associated antigen 90K; Tumor-associated antigen 90K;
抗原和靶标
Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
- Q08380 LG3BP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQFNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTDSSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSLVYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGWKAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q08380 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y41 | Phosphorylation | Uniprot | |
| N69 | N-Glycosylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| N125 | N-Glycosylation | Uniprot | |
| N192 | N-Glycosylation | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| N398 | N-Glycosylation | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| S411 | Phosphorylation | Uniprot | |
| T413 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| Y432 | Phosphorylation | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| S444 | O-Glycosylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| Y458 | Phosphorylation | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| K474 | Ubiquitination | Uniprot | |
| N551 | N-Glycosylation | Uniprot | |
| K554 | Ubiquitination | Uniprot | |
| N580 | N-Glycosylation | Uniprot |
研究背景
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Secreted. Secreted>Extracellular space>Extracellular matrix.
Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation.
文献引用
Application: WB Species: human Sample: Jurkat cells
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