产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12080, RRID:AB_2844885.
展开/折叠
1110064C04Rik; 2410018D16Rik; AI182287; AU022853; Beta regulatory subunit of methionine adenosyltransferase; dTDP 4 keto 6 deoxy D glucose 4 reductase; DTDP-4-keto-6-deoxy-D-glucose 4-reductase; MAT II; MAT II beta; Mat2b; MAT2B_HUMAN; MATIIbeta; Methionine adenosyltransferase 2 beta subunit; Methionine adenosyltransferase 2 subunit beta; Methionine adenosyltransferase II beta; MGC12237; MSTP045; Nbla02999; OTTMUSP00000005600; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase; Putative protein product of Nbla02999; RP23-382C18.2; SDR23E1; Short chain dehydrogenase/reductase family 23E member 1; TGR;
抗原和靶标
- Q9NZL9 MAT2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NZL9 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Ubiquitination | Uniprot | ||
| S9 | Phosphorylation | Uniprot | |
| T34 | Phosphorylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| K46 | Acetylation | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| T280 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| T309 | Phosphorylation | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| K326 | Ubiquitination | Uniprot |
研究背景
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
Widely expressed.
Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
研究领域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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