产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12082, RRID:AB_2844887.
展开/折叠
3 oxoacid CoA transferase 1; 3-oxoacid CoA-transferase 1; EC 2.8.3.5; OTTHUMP00000120012; OTTHUMP00000221550; OXCT; Oxct1; SCOT; Scot S; Scot-S; SCOT1_HUMAN; Somatic type succinyl CoA:3 oxoacid CoA transferase; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Succinyl CoA:3 ketoacid CoA transferase; Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial; Succinyl CoA:3 oxoacid CoA transferase; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial;
抗原和靶标
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
- P55809 SCOT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEADADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDKKKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P55809 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T86 | Phosphorylation | Uniprot | |
| S114 | Phosphorylation | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| Y126 | Phosphorylation | Uniprot | |
| R146 | Methylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| T163 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| Y174 | Phosphorylation | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| K185 | Acetylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K225 | Acetylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| K406 | Acetylation | Uniprot | |
| K418 | Acetylation | Uniprot | |
| K421 | Acetylation | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| T435 | Phosphorylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K455 | Acetylation | Uniprot | |
| K463 | Ubiquitination | Uniprot | |
| K473 | Acetylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| K480 | Acetylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K481 | Acetylation | Uniprot | |
| K482 | Acetylation | Uniprot | |
| S509 | Phosphorylation | Uniprot |
研究背景
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Mitochondrion matrix.
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
Homodimer.
Belongs to the 3-oxoacid CoA-transferase family.
研究领域
· Metabolism > Lipid metabolism > Synthesis and degradation of ketone bodies.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Carbohydrate metabolism > Butanoate metabolism.
限制条款
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