SQRDL Antibody - #DF12087

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产品: SQRDL 抗体
货号: DF12087
描述: Rabbit polyclonal antibody to SQRDL
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Horse, Sheep, Rabbit, Dog
分子量: 50kd; 50kD(Calculated).
蛋白号: Q9Y6N5
RRID: AB_2844892

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(86%), Horse(100%), Sheep(88%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
SQRDL Antibody detects endogenous levels of total SQRDL.
RRID:
AB_2844892
引用格式: Affinity Biosciences Cat# DF12087, RRID:AB_2844892.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

0610039J17Rik; 4930557M22Rik; CGI 44; CGI44; mitochondrial; PRO1975; SQRD_HUMAN; Sqrdl; Sulfide dehydrogenase like; Sulfide quinone reductase like; Sulfide quinone reductase-like (yeast); Sulfide:quinone oxidoreductase; Sulfide:quinone oxidoreductase, mitochondrial;

抗原和靶标

免疫原:
Uniprot:

Q9Y6N5(SQOR_HUMAN) >>Visit HPA database.

基因/基因ID:
SQOR(58472)
序列:
MVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTLVGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDKPGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDRTISVIMKNQTPTKKYDGYTSCPLVTGYNRVILAEFDYKAEPLETFPFDQSKERLSMYLMKADLMPFLYWNMMLRGYWGGPAFLRKLFHLGMS

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Dog
100
Rabbit
100
Sheep
88
Zebrafish
86
Xenopus
75
Bovine
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9Y6N5 作为底物

Site PTM Type Enzyme
K115 Acetylation
K125 Ubiquitination
K135 Acetylation
S137 Phosphorylation
Y151 Phosphorylation
K155 Ubiquitination
K165 Ubiquitination
K173 Acetylation
K173 Ubiquitination
K177 Ubiquitination
K180 Acetylation
K186 Acetylation
K186 Ubiquitination
T197 Phosphorylation
Y259 Phosphorylation
K260 Acetylation
K261 Ubiquitination
K320 Acetylation
T338 Phosphorylation
T342 Phosphorylation
S343 Phosphorylation
S361 Phosphorylation
Y395 Phosphorylation
S408 Phosphorylation
K409 Ubiquitination
S413 Phosphorylation
Y415 Phosphorylation
K443 Acetylation
S450 Phosphorylation

研究背景

功能:

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

细胞定位:

Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the SQRD family.

研究领域

· Metabolism > Energy metabolism > Sulfur metabolism.

文献引用

1). Clinical significance of Interleukin 17 receptor E in diabetic nephropathy. International Immunopharmacology, 2023 (PubMed: 37235960) [IF=5.6]

Application: IF/ICC    Species: Human    Sample: renal biopsy tissues

Fig. 4. Immunofluorescence double staining of IL-17RE and specific tubular/glomerular markers in renal biopsy tissues of patients with DN. IL-17RE was marked with FITC-conjugated secondary antibody; proximal tubular epithelial, distal tubular epithelial, and collecting duct cells were marked as AQP1, CD28k, and AQP3 with Cy3-conjugated secondary antibody, respectively; glomerular podocytes and endothelial and mesangial cells were marked as synaptopodin, CD31, and PDGFR-β with Cy3-conjugated secondary antibody, respectively. The white arrow indicates the positive staining area. NGAL, AQP1, CD28k, and AQP3: scale bar = 50 μm; synaptopodin, CD31, and PDGFR-β: scale bar = 25 μm. AQP, Aquaporin; CD28k, Calbindin D28k; PDGFR-β, platelet-derived growth factor receptors beta.

Application: IHC    Species: Human    Sample: renal biopsy tissues

Fig. 5. Pathological staining and protein expression levels in mouse kidney tissues. (A) H&E staining of the mouse kidneys. Scale bar = 50 μm. (B) PAS staining of mouse kidneys. Scale bar = 50 μm. (C) IHC assay of NGAL protein expression in the mouse kidneys. Scale bar = 50 μm. (D) IHC assay of IL-17RE protein expression in the mouse kidneys. Scale bar = 50 μm. The results represent the mean ± SD for six samples/group. *P < 0.05, ***P < 0.001 vs db/m. H&E, haematoxylin and eosin staining; PAS, periodic acid-Schiff staining; IHC, immunohistochemical staining.

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