HMGCS1 Antibody - #DF12100

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产品: HMGCS1 抗体
货号: DF12100
描述: Rabbit polyclonal antibody to HMGCS1
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 57 kDa; 57kD(Calculated).
蛋白号: Q01581
RRID: AB_2844905

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Zebrafish(86%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
HMGCS1 Antibody detects endogenous levels of total HMGCS1.
RRID:
AB_2844905
引用格式: Affinity Biosciences Cat# DF12100, RRID:AB_2844905.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble); 3-hydroxy-3-methylglutaryl coenzyme A synthase; cytoplasmic; EC 2.3.3.10; HMCS1_HUMAN; HMG CoA synthase; HMG-CoA synthase; HMGCS; HMGCS1; Hydroxymethylglutaryl CoA synthase, cytoplasmic; Hydroxymethylglutaryl-CoA synthase; MGC90332;

抗原和靶标

免疫原:
Uniprot:

Q01581(HMCS1_HUMAN) >>Visit HPA database.

基因/基因ID:
HMGCS1(3157)
序列:
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
86
Pig
0
Bovine
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q01581 作为底物

Site PTM Type Enzyme
S4 Phosphorylation
K46 Acetylation
K46 Ubiquitination
S67 Phosphorylation
C86 S-Nitrosylation
T96 Phosphorylation
K100 Ubiquitination
S101 Phosphorylation
K206 Acetylation
K206 Ubiquitination
Y213 Phosphorylation
S221 Phosphorylation
S227 Phosphorylation
K239 Ubiquitination
K246 Acetylation
K246 Ubiquitination
K273 Acetylation
K273 Ubiquitination
K291 Ubiquitination
S293 Phosphorylation
S296 Phosphorylation
K305 Sumoylation
K305 Ubiquitination
Y310 Phosphorylation
R313 Methylation
K317 Acetylation
K317 Ubiquitination
K321 Acetylation
K321 Ubiquitination
K330 Ubiquitination
S361 Phosphorylation
K368 Ubiquitination
K400 Ubiquitination
K409 Acetylation
K409 Ubiquitination
S414 Phosphorylation
K428 Ubiquitination
T471 Phosphorylation
T476 Phosphorylation
S486 Phosphorylation
T490 Phosphorylation
S495 Phosphorylation P06493 (CDK1)
K498 Ubiquitination
K499 Ubiquitination
S516 Phosphorylation

研究背景

功能:

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer.

蛋白家族:

Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

研究领域

· Metabolism > Lipid metabolism > Synthesis and degradation of ketone bodies.

· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.

· Metabolism > Carbohydrate metabolism > Butanoate metabolism.

· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

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