产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12107, RRID:AB_2844912.
展开/折叠
A BETA; A SCS; ATP specific succinyl CoA synthetase subunit beta; ATP specific succinyl CoA synthetase, beta subunit; ATP-specific succinyl-CoA synthetase subunit beta; Mitochondrial succinyl CoA ligase [ADP forming] subunit beta; MTDPS5; Renal carcinoma antigen NY-REN-39; Renal carcinoma antigen NYREN39; SCS betaA; SCS-betaA; SUCB1_HUMAN; Succinate CoA ligase (ADP forming); Succinate CoA ligase [ADP forming] subunit beta, mitochondrial; succinyl CoA ligase [ADP forming] subunit beta, mitochondrial; Succinate CoA ligase ADP forming beta subunit; Succinate CoA ligase beta subunit; Succinyl CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl CoA synthetase beta A chain; Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase beta-A chain; SUCLA2;
抗原和靶标
- Q9P2R7 SUCB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9P2R7 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S4 | Phosphorylation | Uniprot | |
S70 | Phosphorylation | Uniprot | |
Y75 | Phosphorylation | Uniprot | |
K78 | Acetylation | Uniprot | |
K78 | Ubiquitination | Uniprot | |
S79 | Phosphorylation | Uniprot | |
Y84 | Phosphorylation | Uniprot | |
K88 | Acetylation | Uniprot | |
K88 | Ubiquitination | Uniprot | |
K89 | Acetylation | Uniprot | |
K89 | Ubiquitination | Uniprot | |
K93 | Ubiquitination | Uniprot | |
R106 | Methylation | Uniprot | |
K108 | Acetylation | Uniprot | |
K108 | Ubiquitination | Uniprot | |
K116 | Acetylation | Uniprot | |
K116 | Ubiquitination | Uniprot | |
K120 | Ubiquitination | Uniprot | |
S124 | Phosphorylation | Uniprot | |
K129 | Ubiquitination | Uniprot | |
S132 | Phosphorylation | Uniprot | |
K138 | Ubiquitination | Uniprot | |
K143 | Acetylation | Uniprot | |
K143 | Ubiquitination | Uniprot | |
K216 | Ubiquitination | Uniprot | |
S235 | Phosphorylation | Uniprot | |
S279 | Phosphorylation | Uniprot | |
S281 | Phosphorylation | Uniprot | |
K287 | Ubiquitination | Uniprot | |
T295 | Phosphorylation | Uniprot | |
K302 | Acetylation | Uniprot | |
T341 | Phosphorylation | Uniprot | |
K368 | Acetylation | Uniprot | |
K417 | Ubiquitination | Uniprot | |
S444 | Phosphorylation | Uniprot | |
T448 | Phosphorylation | Uniprot |
研究背景
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity).
Mitochondrion.
Widely expressed. Not expressed in liver and lung.
Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP (By similarity). Interacts with ALAS2.
Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
研究领域
· Metabolism > Carbohydrate metabolism > Citrate cycle (TCA cycle).
· Metabolism > Carbohydrate metabolism > Propanoate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
限制条款
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