Cyclin L1 Antibody - #AF0236

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产品: Cyclin L1 抗体
货号: AF0236
描述: Rabbit polyclonal antibody to Cyclin L1
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 60kDa; 60kD(Calculated).
蛋白号: Q9UK58
RRID: AB_2833411

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
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MS Report
HPLC Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
Cyclin L1 Antibody detects endogenous levels of total Cyclin L1.
RRID:
AB_2833411
引用格式: Affinity Biosciences Cat# AF0236, RRID:AB_2833411.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Ania 6a; CCNL1; CCNL1_HUMAN; Cyclin L; Cyclin L gamma; Cyclin L1; Cyclin-L; Cyclin-L1;

抗原和靶标

免疫原:
Uniprot:

Q9UK58(CCNL1_HUMAN) >>Visit HPA database.

基因/基因ID:
CCNL1(57018)
表达:
Q9UK58 CCNL1_HUMAN:

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).

描述:
CCNL1 cyclin L1, a member of the cyclin family. Associates with the PITSLRE kinase and is involved in pre-mRNA processing.
序列:
MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
75
Zebrafish
46
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9UK58 作为底物

Site PTM Type Enzyme
T30 Phosphorylation
T32 Phosphorylation
T33 Phosphorylation
T37 Phosphorylation
S65 Phosphorylation
T67 Phosphorylation
S166 Phosphorylation
K178 Ubiquitination
Y289 Phosphorylation
T325 Phosphorylation
S329 Phosphorylation
T330 Phosphorylation
S335 Phosphorylation
S338 Phosphorylation
S341 Phosphorylation
S342 Phosphorylation
S352 Phosphorylation
S355 Phosphorylation
S372 Phosphorylation
S374 Phosphorylation
Y376 Phosphorylation
S401 Phosphorylation
S403 Phosphorylation
S405 Phosphorylation
S417 Phosphorylation
S419 Phosphorylation
T421 Phosphorylation
Y422 Phosphorylation
S424 Phosphorylation
S445 Phosphorylation
K449 Acetylation
K451 Acetylation
S470 Phosphorylation
R471 Methylation
R473 Methylation
K486 Ubiquitination
K487 Ubiquitination
S502 Phosphorylation
S504 Phosphorylation
K512 Methylation

研究背景

功能:

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC).

细胞定位:

Nucleus speckle. Nucleus>Nucleoplasm.
Note: Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).

亚基结构:

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK12 and CDK13. Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.

蛋白家族:

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.

Belongs to the cyclin family. Cyclin L subfamily.

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