产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0236, RRID:AB_2833411.
展开/折叠
Ania 6a; CCNL1; CCNL1_HUMAN; Cyclin L; Cyclin L gamma; Cyclin L1; Cyclin-L; Cyclin-L1;
抗原和靶标
Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
- Q9UK58 CCNL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UK58 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T30 | Phosphorylation | Uniprot | |
| T32 | Phosphorylation | Uniprot | |
| T33 | Phosphorylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| Y289 | Phosphorylation | Uniprot | |
| T325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| T330 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| Y376 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| T421 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| K449 | Acetylation | Uniprot | |
| K451 | Acetylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| R471 | Methylation | Uniprot | |
| R473 | Methylation | Uniprot | |
| K486 | Ubiquitination | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| K512 | Methylation | Uniprot |
研究背景
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC).
Nucleus speckle. Nucleus>Nucleoplasm.
Note: Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK12 and CDK13. Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.
Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
Belongs to the cyclin family. Cyclin L subfamily.
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