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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12180, RRID:AB_2844985.
展开/折叠
65K; CGI 21; CGI-21; FLJ33136; HSPC332; Inactive ubiquitin specific peptidase 39; Inactive ubiquitin-specific peptidase 39; MGC75069; PRO2855; S. CEREVISIAE, HOMOLOG OF SAD1; SAD1; SAD1 homolog; Small nuclear ribonucleoprotein 65kDa (U4/U6.U5); snRNP ASSEMBLY DEFECTIVE 1; SnRNP assembly defective 1 homolog; SNRNP65; SNUT2_HUMAN; U4/U6.U5 tri snRNP associated 65 kDa protein; U4/U6.U5 tri snRNP associated protein 2; U4/U6.U5 tri-snRNP-associated 65 kDa protein; U4/U6.U5 tri-snRNP-associated protein 2; Ubiquitin specific peptidase 39; Ubiquitin specific protease 39; USP39;
抗原和靶标
- Q53GS9 SNUT2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDFEKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQGA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q53GS9 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S42 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| C105 | S-Nitrosylation | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| Y259 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K291 | Methylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K428 | Acetylation | Uniprot | |
| K428 | Ubiquitination | Uniprot | |
| K434 | Ubiquitination | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| R481 | Methylation | Uniprot | |
| K508 | Ubiquitination | Uniprot |
研究背景
Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity.
Nucleus.
The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.
Belongs to the peptidase C19 family.
研究领域
· Genetic Information Processing > Transcription > Spliceosome.
文献引用
Application: IHC Species: Human Sample: neck squamous cell carcinoma (HNSCC) tumor and adjacent tissues
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