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| 产品: | CPLX1 抗体 |
| 货号: | DF12192 |
| 描述: | Rabbit polyclonal antibody to CPLX1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 15-20 kDa; 15kD(Calculated). |
| 蛋白号: | O14810 |
| RRID: | AB_2844997 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12192, RRID:AB_2844997.
展开/折叠
921-S; complexin 1; Complexin I; Complexin-1; CPLX1; CPLX1_HUMAN; CPX I; CPX-I; CPX1; Synaphin 2; Synaphin-2;
抗原和靶标
Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
- O14810 CPLX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O14810 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K14 | Acetylation | Uniprot | |
| T95 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot |
研究背景
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Cytoplasm>Cytosol. Perikaryon. Cell junction>Synapse>Presynapse.
Note: Enriched at synaptic-releasing sites in mature neurons.
Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
Belongs to the complexin/synaphin family.
研究领域
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
文献引用
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