产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12247, RRID:AB_2845052.
展开/折叠
26g turgor protein homolog; AL7A1_HUMAN; Aldehyde dehydrogenase 7 A1; Aldehyde dehydrogenase 7 family, member A1; Aldehyde dehydrogenase family 7 member A1; ALDH7A1; Alpha AASA dehydrogenase; Alpha aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Alpha-aminoadipic semialdehyde dehydrogenase; Antiquitin 1; Antiquitin; Antiquitin-1; ATQ1; Betaine aldehyde dehydrogenase; Delta1 piperideine 6 carboxylate dehydrogenease; Delta1-piperideine-6-carboxylate dehydrogenase; EPD; P6c dehydrogenase; PDE;
抗原和靶标
Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.
- P49419 AL7A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49419 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y39 | Phosphorylation | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| Y88 | Phosphorylation | Uniprot | |
| K93 | Acetylation | Uniprot | |
| K94 | Acetylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| K389 | Acetylation | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| K439 | Acetylation | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| K500 | Ubiquitination | Uniprot | |
| C522 | S-Nitrosylation | Uniprot | |
| K528 | Acetylation | Uniprot | |
| K528 | Ubiquitination | Uniprot | |
| K537 | Ubiquitination | Uniprot |
研究背景
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Cytoplasm>Cytosol. Nucleus.
Mitochondrion.
Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.
Homotetramer.
Belongs to the aldehyde dehydrogenase family.
研究领域
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Carbohydrate metabolism > Ascorbate and aldarate metabolism.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Glycine, serine and threonine metabolism.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Amino acid metabolism > Lysine degradation.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tryptophan metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Lipid metabolism > Glycerolipid metabolism.
· Metabolism > Carbohydrate metabolism > Pyruvate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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