产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12258, RRID:AB_2845063.
展开/折叠
C-Maf-inducing protein; c-Mip; cmip; CMIP_HUMAN; KIAA1694; Tc-Mip; TCMIP; Truncated c-Maf-inducing protein;
抗原和靶标
Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.
- Q8IY22 CMIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDVTSSSGGGGDPRQIEETKPLLGGDVSAPEGTKMGAVPCRRALLLCNGMRYKLLQEGDIQVCVIRHPRTFLSKILTSKFLRRWEPHHLTLADNSLASATPTGYMENSVSYSAIEDVQLLSWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKKKIYKYKKVLSNPSRWEVVLKEIRTLVDMALTSPLQDDSINQAPLEIVSKLLSENTNLTTQEHENIIVAIAPLLENNHPPPDLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMDFGKCPRLRLFTQEYILALNELNAGMEVVKKFIQSMHGPTGHCPHPRVLPNLVAVCLAAIYSCYEEFINSRDNSPSLKEIRNGCQQPCDRKPTLPLRLLHPSPDLVSQEATLSEARLKSVVVASSEIHVEVERTSTAKPALTASAGNDSEPNLIDCLMVSPACSTMSIELGPQADRTLGCYVEILKLLSDYDDWRPSLASLLQPIPFPKEALAHEKFTKELKYVIQRFAEDPRQEVHSCLLSVRAGKDGWFQLYSPGGVACDDDGELFASMVHILMGSCYKTKKFLLSLAENKLGPCMLLALRGNQTMVEILCLMLEYNIIDNNDTQLQIISTLESTDVGKRMYEQLCDRQRELKELQRKGGPTRLTLPSKSTDADLARLLSSGSFGNLENLSLAFTNVTSACAEHLIKLPSLKQLNLWSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGLLALSSMKSLCSLNMNSTKLSADTYEDLKAKLPNLKEVDVRYTEAW
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8IY22 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K20 | Sumoylation | Uniprot | |
| K20 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| T77 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| S349 | Phosphorylation | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| T368 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| T409 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| Y456 | Phosphorylation | Uniprot | |
| K491 | Ubiquitination | Uniprot | |
| K646 | Ubiquitination | Uniprot | |
| S647 | Phosphorylation | Uniprot | |
| T648 | Phosphorylation | Uniprot | |
| S660 | Phosphorylation | Uniprot | |
| S707 | Phosphorylation | Uniprot | |
| S736 | Phosphorylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| K746 | Ubiquitination | Uniprot | |
| Y752 | Phosphorylation | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| Y769 | Phosphorylation | Uniprot |
研究背景
Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
Nucleus. Cytoplasm.
Note: Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343).
Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.
Interacts with FLNA.
限制条款
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