MYO18A Antibody - #DF12298

>>买2送1 进行中>>
>>满百送 进行中>>
>>赠送JD卡 进行中>>
>>3倍积分 进行中>>
(3)  
产品: MYO18A 抗体
货号: DF12298
描述: Rabbit polyclonal antibody to MYO18A
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 230 kDa,190 kDa; 233kD(Calculated).
蛋白号: Q92614
RRID: AB_2845103

浏览相似产品>>

   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

联系销售
相关下载
MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Bovine(92%), Horse(100%), Sheep(92%), Rabbit(83%), Dog(83%), Chicken(82%)
克隆:
Polyclonal
特异性:
MYO18A Antibody detects endogenous levels of total MYO18A.
RRID:
AB_2845103
引用格式: Affinity Biosciences Cat# DF12298, RRID:AB_2845103.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

MAJN; Molecule associated with JAK3 N terminus; Myosin 18A; Myosin containing a PDZ domain; Myosin XVIIIA; MyoXVIIIIA; MYSPDZ; SPR210;

抗原和靶标

免疫原:
Uniprot:

Q92614(MY18A_HUMAN) >>Visit HPA database.

基因/基因ID:
MYO18A(399687)
序列:
MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSLRRGFFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSVILDSGHLSTASSSDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLVQHPGPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHFAEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYLSDSDTEAKLTETNA

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
92
Sheep
92
Dog
83
Rabbit
83
Chicken
82
Pig
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q92614 作为底物

Site PTM Type Enzyme
S29 Phosphorylation
S35 Phosphorylation
S40 Phosphorylation
S51 Phosphorylation
S52 Phosphorylation
S56 Phosphorylation
S63 Phosphorylation
S72 Phosphorylation
S74 Phosphorylation
T79 Phosphorylation
S83 Phosphorylation
S85 Phosphorylation
S89 Phosphorylation
S94 Phosphorylation
S98 Phosphorylation
T99 Phosphorylation
S101 Phosphorylation
S102 Phosphorylation
S103 Phosphorylation
S112 Phosphorylation
S116 Phosphorylation
S126 Phosphorylation
S132 Phosphorylation
K137 Acetylation
S140 Phosphorylation
S142 Phosphorylation
S145 Phosphorylation
S149 Phosphorylation
S151 Phosphorylation
T153 Phosphorylation
S154 Phosphorylation
T155 Phosphorylation
S157 Phosphorylation
S160 Phosphorylation
S164 Phosphorylation
S191 Phosphorylation
T217 Phosphorylation
T228 Phosphorylation
S234 Phosphorylation
K335 Ubiquitination
K351 Ubiquitination
K367 Ubiquitination
K377 Ubiquitination
K381 Ubiquitination
K398 Ubiquitination
Y415 Phosphorylation
Y454 Phosphorylation
S455 Phosphorylation
K457 Acetylation
K463 Methylation
K463 Ubiquitination
S493 Phosphorylation
K637 Ubiquitination
K644 Ubiquitination
K650 Ubiquitination
K719 Ubiquitination
T722 Phosphorylation
S726 Phosphorylation
T727 Phosphorylation
S728 Phosphorylation
S736 Phosphorylation
Y835 Phosphorylation
Y904 Phosphorylation
Y905 Phosphorylation
K913 Ubiquitination
S916 Phosphorylation
S965 Phosphorylation
K967 Sumoylation
K968 Sumoylation
S971 Phosphorylation
S980 Phosphorylation
S985 Phosphorylation
S987 Phosphorylation
S995 Phosphorylation
S1004 Phosphorylation
T1008 Phosphorylation
K1017 Ubiquitination
K1037 Ubiquitination
K1038 Ubiquitination
S1039 Phosphorylation
S1060 Phosphorylation
S1062 Phosphorylation
S1063 Phosphorylation
S1067 Phosphorylation
S1068 Phosphorylation
S1069 Phosphorylation
S1070 Phosphorylation
S1076 Phosphorylation
S1099 Phosphorylation
Y1140 Phosphorylation
S1284 Phosphorylation
S1309 Phosphorylation
K1386 Ubiquitination
T1442 Phosphorylation
S1465 Phosphorylation
S1518 Phosphorylation
R1583 Methylation
K1635 Ubiquitination
S1640 Phosphorylation
T1728 Phosphorylation
S1843 Phosphorylation
S1910 Phosphorylation
S1942 Phosphorylation
S1951 Phosphorylation
S1970 Phosphorylation
S1974 Phosphorylation
S1998 Phosphorylation
S2002 Phosphorylation
S2005 Phosphorylation
S2006 Phosphorylation
S2007 Phosphorylation
T2009 Phosphorylation
S2014 Phosphorylation
S2020 Phosphorylation
T2030 Phosphorylation
Y2035 Phosphorylation
S2036 Phosphorylation
S2038 Phosphorylation
Y2039 Phosphorylation
S2041 Phosphorylation
S2043 Phosphorylation
T2045 Phosphorylation
T2050 Phosphorylation

研究背景

功能:

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity.

细胞定位:

Golgi apparatus. Golgi apparatus>trans-Golgi network. Postsynaptic Golgi apparatus. Cytoplasm>Cytoskeleton>Microtubule organizing center.
Note: Recruited to the Golgi apparatus by GOLPH3 (PubMed:19837035). Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity).

Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm>Cytoskeleton.
Note: Colocalizes with actin.

Cytoplasm.
Note: Lacks the PDZ domain (PubMed:12761286). Diffusely localized in the cytoplasm (PubMed:12761286).

Cell surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A. Binds F-actin; regulated by ADP and GOLPH3. Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with JAK3. Interacts with MSR1 and CD14. Isoform 5 interacts with CD11B.

蛋白家族:

The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (PubMed:23990465).

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

限制条款

产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）

产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.