产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12300, RRID:AB_2845105.
展开/折叠
CI ESSS; Complex I ESSS; complex I NP17.3 subunit; ESSS; FLJ20494; MGC111182; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 11 17.3kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 mitochondrial; NADH ubiquinone oxidoreductase ESSS subunit; NDUFB 11; Neuronal protein 17.3; Np15; NP17.3; P17.3;
抗原和靶标
- Q9NX14 NDUBB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAGLFGLSARRLLAAAATRGLPAARVRWESSFSRTVVAPSAVAGKRPPEPTTPWQEDPEPEDENLYEKNPDSHGYDKDPVLDVWNMRLVFFFGVSIILVLGSTFVAYLPDYRMKEWSRREAERLVKYREANGLPIMESNCFDPSKIQLPEDE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NX14 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R12 | Methylation | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| T52 | Phosphorylation | Uniprot | |
| T53 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| Y128 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot |
研究背景
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Mitochondrion inner membrane>Single-pass membrane protein.
Ubiquitous.
Complex I is composed of 45 different subunits.
Belongs to the complex I NDUFB11 subunit family.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
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