| 产品: | PYGB 抗体 |
| 货号: | DF12308 |
| 描述: | Rabbit polyclonal antibody to PYGB |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 97 kDa; 97kD(Calculated). |
| 蛋白号: | P11216 |
| RRID: | AB_2845113 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12308, RRID:AB_2845113.
展开/折叠
Brain glycogen phosphorylase; Glycogen phosphorylase B; Glycogen phosphorylase brain form; Glycogen Phosphorylase Isoenzyme BB; Glycogen phosphorylase, brain form; MGC9213; Phosphorylase glycogen brain; PYGB; PYGB_HUMAN;
抗原和靶标
- P11216 PYGB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNIPRD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P11216 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K3 | Acetylation | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S15 | Phosphorylation | Q8IWU2 (LMTK2) | Uniprot |
| S31 | Phosphorylation | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| Y52 | Phosphorylation | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| Y85 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| Y162 | Phosphorylation | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| Y197 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| T210 | Phosphorylation | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| T241 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| Y281 | Phosphorylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K316 | Acetylation | Uniprot | |
| C326 | S-Nitrosylation | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| T372 | Phosphorylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| K520 | Ubiquitination | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| K552 | Ubiquitination | Uniprot | |
| Y554 | Phosphorylation | Uniprot | |
| K557 | Ubiquitination | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| K597 | Ubiquitination | Uniprot | |
| K609 | Ubiquitination | Uniprot | |
| K642 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot | |
| Y727 | Phosphorylation | Uniprot | |
| Y732 | Phosphorylation | Uniprot | |
| Y733 | Phosphorylation | Uniprot | |
| K740 | Ubiquitination | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| K796 | Acetylation | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| K811 | Acetylation | Uniprot | |
| K811 | Ubiquitination | Uniprot |
研究背景
Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Phosphorylated. Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A (By similarity).
Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Belongs to the glycogen phosphorylase family.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Metabolism > Carbohydrate metabolism > Starch and sucrose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
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