| 产品: | RQCD1 抗体 |
| 货号: | DF12313 |
| 描述: | Rabbit polyclonal antibody to RQCD1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 34-40 kDa; 34kD(Calculated). |
| 蛋白号: | Q92600 |
| RRID: | AB_2845118 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12313, RRID:AB_2845118.
展开/折叠
CAF40; CCR4-NOT transcription complex subunit 9; Cell differentiation protein RCD1 homolog; CNOT9; CT129; Homo sapiens protein involved in sexual development complete cds; Rcd 1; Rcd-1; Rcd1 (required for cell differentiation, S.pombe) homolog 1; RCD1; RCD1 required for cell differentiation1 homolog; RCD1 required for cell differentiation1 homolog (S. pombe); RCD1+; RCD1_HUMAN; rqcd1;
抗原和靶标
- Q92600 CNOT9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MHSLATAAPVPTTLAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92600 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| T12 | Phosphorylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| C91 | S-Nitrosylation | Uniprot | |
| C99 | S-Nitrosylation | Uniprot | |
| T149 | Phosphorylation | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot |
研究背景
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
Nucleus. Cytoplasm>P-body.
Note: NANOS2 promotes its localization to P-body.
Detected in spleen, thymus, prostate, testis, ovary and intestine.
Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA (By similarity). Interacts with NANOS2 (By similarity). Directly interacts with ZNF335.
Belongs to the CNOT9 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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