产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12316, RRID:AB_2845121.
展开/折叠
1B1075; AI385542; Chgd; SCG3; SCG3_HUMAN; Secretogranin III; Secretogranin-3; SGCG; SgIII;
抗原和靶标
- Q8WXD2 SCG3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8WXD2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| T144 | O-Glycosylation | Uniprot | |
| Y208 | Phosphorylation | Uniprot | |
| T216 | O-Glycosylation | Uniprot | |
| T231 | O-Glycosylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S359 | O-Glycosylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| K397 | Acetylation | Uniprot |
研究背景
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
O-glycosylated.
Cytoplasmic vesicle>Secretory vesicle. Cytoplasmic vesicle>Secretory vesicle membrane>Peripheral membrane protein. Secreted.
Note: Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
Expressed in brain, heart, kidney, liver and skeletal muscle.
Interacts with CHGA (By similarity). Interacts with secretogranin II/SCG2. Interacts (via C-terminus) with CPE (By similarity).
限制条款
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