产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12333, RRID:AB_2845138.
展开/折叠
D9S57E; E Tmod; E tropomodulin; E-Tmod; Erythrocyte tropomodulin; ETMOD; MGC124125; MGC124126; OTTHUMP00000021743; TMOD; Tmod1; TMOD1 protein; TMOD1_HUMAN; Tropomodulin 1; Tropomodulin-1;
抗原和靶标
- P28289 TMOD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P28289 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Q96QT4 (TRPM7) | Uniprot |
| Y3 | Phosphorylation | Uniprot | |
| Y10 | Phosphorylation | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| T54 | Phosphorylation | Q96QT4 (TRPM7) | Uniprot |
| Y87 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| Y242 | Phosphorylation | Uniprot | |
| Y278 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot |
研究背景
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
Cytoplasm>Cytoskeleton.
Note: In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).
Highly expressed in the erythrocyte, heart and skeletal muscle.
Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.
Belongs to the tropomodulin family.
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