ACAA1 Antibody - #DF12345

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产品: ACAA1 抗体
货号: DF12345
描述: Rabbit polyclonal antibody to ACAA1
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 41 kDa; 44kD(Calculated).
蛋白号: P09110
RRID: AB_2845150

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(92%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(83%)
克隆:
Polyclonal
特异性:
ACAA1 Antibody detects endogenous levels of total ACAA1.
RRID:
AB_2845150
引用格式: Affinity Biosciences Cat# DF12345, RRID:AB_2845150.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

3 ketoacyl CoA thiolase peroxisomal; 3-ketoacyl-CoA thiolase; ACAA; ACAA1; Acetyl CoA acyltransferase 1; Acetyl Coenzyme A acyltransferase 1; Acetyl-CoA acyltransferase; Acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3 oxoacyl Coenzyme A; Beta ketothiolase; Beta-ketothiolase; Peroxisomal 3 oxoacyl CoA thiolase; Peroxisomal 3 oxoacyl Coenzyme A thiolase; Peroxisomal 3-oxoacyl-CoA thiolase; peroxisomal; PTHIO; THIK_HUMAN; THIO;

抗原和靶标

免疫原:
Uniprot:

P09110(THIK_HUMAN) >>Visit HPA database.

基因/基因ID:
ACAA1(30)
序列:
MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Zebrafish
92
Xenopus
83
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P09110 作为底物

Site PTM Type Enzyme
T59 Phosphorylation
T60 Phosphorylation
T70 Phosphorylation
S124 Phosphorylation
S125 Phosphorylation
S132 Phosphorylation
S141 Phosphorylation
S166 Phosphorylation
K198 Acetylation
K198 Ubiquitination
K209 Ubiquitination
K234 Acetylation
K237 Acetylation
S251 Phosphorylation
T252 Phosphorylation
K259 Acetylation
S269 Phosphorylation
S291 Phosphorylation
K292 Ubiquitination
Y323 Phosphorylation
S337 Phosphorylation
T389 Phosphorylation
K395 Acetylation

研究背景

细胞定位:

Peroxisome.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer.

蛋白家族:

Belongs to the thiolase-like superfamily. Thiolase family.

研究领域

· Cellular Processes > Transport and catabolism > Peroxisome.   (View pathway)

· Metabolism > Lipid metabolism > Fatty acid degradation.

· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.

· Metabolism > Lipid metabolism > alpha-Linolenic acid metabolism.

· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.

· Metabolism > Global and overview maps > Metabolic pathways.

· Metabolism > Global and overview maps > Fatty acid metabolism.

· Organismal Systems > Endocrine system > PPAR signaling pathway.

文献引用

1). Transcriptome and proteomics conjoint analysis reveal anti-alcoholic liver injury effect of Dianhong Black Tea volatile substances. Food science & nutrition, 2024 (PubMed: 38268900) [IF=3.9]

Application: WB    Species: Rat    Sample:

FIGURE 5 DBTVS decreased the expression of FADS2, CD36, and ACAA1. (a) Representative blots of FADS2, CYP7A1, CD36, ACSL1, ACAA1, and HMGCS2. (b) The protein expression levels of FADS2 between different groups. (c) The protein expression levels of CYP7A1 between different groups. (d) The protein expression levels of CD36 between different groups. (e) The protein expression levels of ACSL1 between different groups. (f) The protein expression levels of ACAA1 between different groups. (g) The protein expression levels of HMGCS2 between different groups. Data were presented as mean ± SD. Multiple groups were tested by one‐way ANOVA followed by Dunnett‐t test for all statistical analyses. *p 

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