产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12349, RRID:AB_2845154.
展开/折叠
Arhgdib; D4; D4 GDP dissociation inhibitor; GDIA 2; GDIA2; GDID 4; GDID4; GDIR2_HUMAN; GDP dissociation inhibitor D4; LY GDI; Ly-GDI; LYGDI; MGC108926; RAP1GN1; Rho GDI 2; Rho GDI beta; Rho GDI2; Rho GDP dissociation inhibitor (GDI) beta; Rho GDP dissociation inhibitor 2; Rho GDP dissociation inhibitor beta; Rho GDP-dissociation inhibitor 2; Rho-GDI beta; RhoGDI2;
抗原和靶标
- P52566 GDIR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEKAPEPHVEEDDDDELDSKLNYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPGPITMDLTGDLEALKKETIVLKEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDDDKQDHLSWEWNLSIKKEWTE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P52566 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K4 | Acetylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| K21 | Acetylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| Y24 | Phosphorylation | P12931 (SRC) , P43405 (SYK) | Uniprot |
| K25 | Acetylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| K30 | Acetylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| S31 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K33 | Acetylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K40 | Acetylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K47 | Acetylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| Y48 | Phosphorylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| T51 | Phosphorylation | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| K63 | Acetylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| C76 | S-Nitrosylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| K95 | Acetylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K102 | Acetylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K124 | Acetylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| Y130 | Phosphorylation | Uniprot | |
| K135 | Acetylation | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| K138 | Acetylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | P12931 (SRC) | Uniprot |
| T157 | Phosphorylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K175 | Acetylation | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| T179 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| K197 | Acetylation | Uniprot |
研究背景
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.
Cytoplasm>Cytosol.
Detected in bone marrow, thymus and spleen.
Interacts with RHOA. Interacts with RAC1. Interacts with RAC2. Interacts with CDC42.
Belongs to the Rho GDI family.
研究领域
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
限制条款
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