| 产品: | CTNNA3 抗体 |
| 货号: | DF12375 |
| 描述: | Rabbit polyclonal antibody to CTNNA3 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Dog, Chicken |
| 分子量: | 100 kDa; 100kD(Calculated). |
| 蛋白号: | Q9UI47 |
| RRID: | AB_2845180 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12375, RRID:AB_2845180.
展开/折叠
4930429L08Rik; 4933408A16; Alpha catenin like protein; Alpha T catenin; Alpha T-catenin; Cadherin associated protein; Cadherin-associated protein; Catenin alpha 3; Catenin alpha-3; Catna3; CTNA3_HUMAN; CTNNA3; MGC26194; MGC75041; OTTHUMP00000019684; OTTMUSP00000028119; OTTMUSP00000028120; RP11-433J16.1; VR22;
抗原和靶标
Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.
- Q9UI47 CTNA3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQEATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKSPNQRDEIAGARASLKENSPLLHSICSACLEHSDVASLKASKDTVCEEIQNALNVISNASQGIQNMTTPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLEKRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNAGKKERSNTLNIALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLVLIEAAKNGREKEIKEYAAIFHEHTSRLVEVANLACSMSTNEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAVKNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIALRDQDADNLDRAAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIPEFVTQVNVALEALSKSSLNVLDDNQFVDISKKIYDTIHDIRCSVMMIRTPEELEDVSDLEEEHEVRSHTSIQTEGKTDRAKMTQLPEAEKEKIAEQVADFKKVKSKLDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTSLIQAAKNLMNAVVQTVKMSYIASTKIIRIQSPAGPRHPVVMWRMKAPAKKPLIKREKPEETCAAVRRGSAKKKIHPLQVMSEFRGRQIY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UI47 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S56 | Phosphorylation | Uniprot | |
| K117 | Acetylation | Uniprot | |
| Y174 | Phosphorylation | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| K190 | Acetylation | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| T552 | Phosphorylation | Uniprot | |
| Y614 | Phosphorylation | Uniprot | |
| S637 | Phosphorylation | Uniprot | |
| S650 | Phosphorylation | Uniprot | |
| T657 | Phosphorylation | Uniprot | |
| T663 | Phosphorylation | Uniprot | |
| K681 | Acetylation | Uniprot | |
| K682 | Acetylation | Uniprot | |
| S837 | Phosphorylation | Uniprot | |
| K860 | Acetylation | Uniprot | |
| T867 | Phosphorylation | Uniprot | |
| Y895 | Phosphorylation | Uniprot |
研究背景
May be involved in formation of stretch-resistant cell-cell adhesion complexes.
Cytoplasm>Cytoskeleton.
Note: Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2.
Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.
Interacts with CTNNB1.
Belongs to the vinculin/alpha-catenin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Endometrial cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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