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| 产品: | LETM1 抗体 |
| 货号: | DF12417 |
| 描述: | Rabbit polyclonal antibody to LETM1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 83 kDa; 83kD(Calculated). |
| 蛋白号: | O95202 |
| RRID: | AB_2845222 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12417, RRID:AB_2845222.
展开/折叠
LETM 1; LETM1 and EF hand domain containing protein 1, mitochondrial; LETM1 and EF-hand domain-containing protein 1; Letm1; LETM1_HUMAN; Leucine zipper EF hand containing transmembrane protein 1; Leucine zipper-EF-hand-containing transmembrane protein 1; Mdm38 homolog; mitochondrial;
抗原和靶标
- O95202 LETM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95202 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| Y141 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| Y164 | Phosphorylation | Uniprot | |
| T175 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K284 | Acetylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| R307 | Methylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| R393 | Methylation | Uniprot | |
| Y579 | Phosphorylation | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| K597 | Acetylation | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| T643 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| K682 | Ubiquitination | Uniprot | |
| S739 | Phosphorylation | Uniprot |
研究背景
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion.
Mitochondrion inner membrane>Single-pass membrane protein.
Homohexamer (By similarity). Can form 2 complexes: a major (300 kDa) and a minor complex (500-600 kDa). Interacts with BCS1L.
Belongs to the LETM1 family.
文献引用
Application: WB Species: human Sample: GC cell lines and tissues
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