产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12421, RRID:AB_2845226.
展开/折叠
130 kDa leucine-rich protein; gp130; Leucine-rich PPR motif-containing protein; Leucine-rich PPR-motif containing protein; LPPRC_HUMAN; LRP 130; lrpprc; mitochondrial;
抗原和靶标
Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes.
- P42704 LPPRC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYAIAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFEFYAQQLRKLRENSS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P42704 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| K107 | Acetylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| R128 | Methylation | Uniprot | |
| C130 | S-Nitrosylation | Uniprot | |
| K138 | Acetylation | Uniprot | |
| K155 | Acetylation | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| Y160 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| K187 | Acetylation | Uniprot | |
| R197 | Methylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| Y270 | Phosphorylation | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K292 | Acetylation | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| Y334 | Phosphorylation | Uniprot | |
| K396 | Acetylation | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| S536 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| R605 | Methylation | Uniprot | |
| Y607 | Phosphorylation | Uniprot | |
| K613 | Acetylation | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| K617 | Sumoylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| Y623 | Phosphorylation | Uniprot | |
| Y633 | Phosphorylation | Uniprot | |
| K649 | Acetylation | Uniprot | |
| K649 | Ubiquitination | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| T660 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| K726 | Acetylation | Uniprot | |
| R739 | Methylation | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| K750 | Acetylation | Uniprot | |
| K777 | Acetylation | Uniprot | |
| K851 | Acetylation | Uniprot | |
| K864 | Acetylation | Uniprot | |
| K868 | Acetylation | Uniprot | |
| S882 | Phosphorylation | Uniprot | |
| N903 | Phosphorylation | Uniprot | |
| T913 | Phosphorylation | Uniprot | |
| S920 | Phosphorylation | Uniprot | |
| R929 | Methylation | Uniprot | |
| C930 | S-Nitrosylation | Uniprot | |
| Y958 | Phosphorylation | Uniprot | |
| K980 | Ubiquitination | Uniprot | |
| Y1016 | Phosphorylation | Uniprot | |
| S1022 | Phosphorylation | Uniprot | |
| S1025 | Phosphorylation | Uniprot | |
| S1026 | Phosphorylation | Uniprot | |
| S1029 | Phosphorylation | Uniprot | |
| T1031 | Phosphorylation | Uniprot | |
| Y1052 | Phosphorylation | Uniprot | |
| Y1070 | Phosphorylation | Uniprot | |
| Y1082 | Phosphorylation | Uniprot | |
| T1084 | Phosphorylation | Uniprot | |
| K1098 | Ubiquitination | Uniprot | |
| T1136 | Phosphorylation | Uniprot | |
| S1138 | Phosphorylation | Uniprot | |
| K1163 | Ubiquitination | Uniprot | |
| S1171 | Phosphorylation | Uniprot | |
| S1175 | Phosphorylation | Uniprot | |
| Y1215 | Phosphorylation | Uniprot | |
| Y1220 | Phosphorylation | Uniprot | |
| K1224 | Acetylation | Uniprot | |
| Y1251 | Phosphorylation | Uniprot | |
| C1277 | S-Nitrosylation | Uniprot | |
| S1306 | Phosphorylation | Uniprot | |
| K1317 | Acetylation | Uniprot | |
| Y1321 | Phosphorylation | Uniprot | |
| S1323 | Phosphorylation | Uniprot | |
| S1327 | Phosphorylation | Uniprot | |
| K1332 | Acetylation | Uniprot | |
| Y1341 | Phosphorylation | Uniprot | |
| T1345 | Phosphorylation | Uniprot | |
| K1350 | Ubiquitination | Uniprot | |
| Y1382 | Phosphorylation | Uniprot |
研究背景
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).
Mitochondrion. Nucleus>Nucleoplasm. Nucleus inner membrane. Nucleus outer membrane.
Note: Seems to be predominantly mitochondrial.
Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes.
Interacts with CECR2, HEBP2, MAP1S and UXT. Interacts with PPARGC1A. Interacts with FOXO1 (By similarity). Component of mRNP complexes associated with HNRPA1.
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