产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12465, RRID:AB_2845270.
展开/折叠
Brain synembrin; brain synembryn; hSyn; Protein Ric-8B; resistance to inhibitors of cholinesterase 8 homolog B (C. elegans); RIC8, C. elegans, homolog of, B; Ric8b; RIC8B_HUMAN; Synembryn, C. elegans, homolog of, B; Synembryn-B;
抗原和靶标
- Q9NVN3 RIC8B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPTTCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NVN3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| T414 | Phosphorylation | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| T473 | Phosphorylation | Uniprot | |
| K484 | Ubiquitination | Uniprot |
研究背景
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.
Cytoplasm>Cell cortex.
Note: Localizes to the cell cortex.
Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
Belongs to the synembryn family.
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