| 产品: | SUGT1 抗体 |
| 货号: | DF12481 |
| 描述: | Rabbit polyclonal antibody to SUGT1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Sheep, Chicken |
| 分子量: | 38 kDa and 41 kDa; 41kD(Calculated). |
| 蛋白号: | Q9Y2Z0 |
| RRID: | AB_2845286 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12481, RRID:AB_2845286.
展开/折叠
Protein 40 6 3; Protein 40-6-3; Protein SGT1 homolog; Putative 40 6 3 protein; Sgt1; SGT1 suppressor of G2 allele of SKP1; SGT1_HUMAN; SGT1B protein; sugt1; Suppressor of G2 allele of SKP1 homolog; Suppressor of G2 allele of SKP1 S. cerevisiae homolog of;
抗原和靶标
- Q9Y2Z0 SGT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAAAGTATSQRFFQSFSDALIDEDPQAALEELTKALEQKPDDAQYYCQRAYCHILLGNYCVAVADAKKSLELNPNNSTAMLRKGICEYHEKNYAAALETFTEGQKLDIETGFHRVGQAGLQLLTSSDPPALDSQSAGITGADANFSVWIKRCQEAQNGSESEVWTHQSKIKYDWYQTESQVVITLMIKNVQKNDVNVEFSEKELSALVKLPSGEDYNLKLELLHPIIPEQSTFKVLSTKIEIKLKKPEAVRWEKLEGQGDVPTPKQFVADVKNLYPSSSPYTRNWDKLVGEIKEEEKNEKLEGDAALNRLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKKY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y2Z0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| Y48 | Phosphorylation | Uniprot | |
| C49 | S-Nitrosylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| C88 | S-Nitrosylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| Y95 | Phosphorylation | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| T265 | Phosphorylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| Y283 | Phosphorylation | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K295 | Sumoylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| Y317 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| S331 | Phosphorylation | P53350 (PLK1) | Uniprot |
| S335 | Phosphorylation | Uniprot | |
| T338 | Phosphorylation | Uniprot | |
| S345 | Phosphorylation | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K351 | Ubiquitination | Uniprot | |
| Y365 | Phosphorylation | Uniprot |
研究背景
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
Cytoplasm. Nucleus.
Note: Translocates to the nucleus upon heat shock, requiring S100A6.
Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.
The CS domain mediates interaction with HSP90.
Belongs to the SGT1 family.
研究领域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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