| 产品: | TRPC4AP 抗体 |
| 货号: | DF12491 |
| 描述: | Rabbit polyclonal antibody to TRPC4AP |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Sheep, Dog |
| 分子量: | 91 kDa; 91kD(Calculated). |
| 蛋白号: | Q8TEL6 |
| RRID: | AB_2845296 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12491, RRID:AB_2845296.
展开/折叠
C20orf188; TRPC4AP; Chromosome 20 open reading frame 188; Protein TAP1; Protein TRUSS; Short transient receptor potential channel 4 associated protein; Short transient receptor potential channel 4-associated protein; TAP1 protein; TNF receptor ubiquitous scaffolding/signaling protein; TNF-receptor ubiquitous scaffolding/signaling protein; TP4AP_HUMAN; Transient receptor potential cation channel, subfamily C, member 4 associated protein; Trp4 associated protein; Trp4-associated protein; Trpc4 associated protein; Trpc4-associated protein; TRPC4AP; TRRP4AP; TRUSS; Tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein;
抗原和靶标
- Q8TEL6 TP4AP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHTTSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQASIVFPPPGASEENGLPHTSARTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8TEL6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| R14 | Methylation | Uniprot | |
| R16 | Methylation | Uniprot | |
| K67 | Acetylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K157 | Acetylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K164 | Acetylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| T265 | Phosphorylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| K472 | Ubiquitination | Uniprot | |
| K490 | Ubiquitination | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| K557 | Ubiquitination | Uniprot | |
| K598 | Ubiquitination | Uniprot | |
| K602 | Ubiquitination | Uniprot | |
| K719 | Ubiquitination | Uniprot | |
| K720 | Ubiquitination | Uniprot |
研究背景
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts directly with DDB1. Interacts with MYC.
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