ZFYVE16 Antibody - #DF12507

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产品: ZFYVE16 抗体
货号: DF12507
描述: Rabbit polyclonal antibody to ZFYVE16
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Dog, Chicken
分子量: 169 kDa,250 kDa; 169kD(Calculated).
蛋白号: Q7Z3T8
RRID: AB_2845312

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MS Report
HPLC Report
MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Bovine(92%), Horse(85%), Sheep(92%), Dog(85%), Chicken(83%)
克隆:
Polyclonal
特异性:
ZFYVE16 Antibody detects endogenous levels of total ZFYVE16.
RRID:
AB_2845312
引用格式: Affinity Biosciences Cat# DF12507, RRID:AB_2845312.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AI035632; B130024H06Rik; B130031L15; DKFZp686E13162; Endofin; Endosomal associated FYVE domain protein; Endosome associated FYVE domain protein; Endosome-associated FYVE domain protein; KIAA0305; KIAA0305;; mKIAA0305; OTTMUSP00000029589; RGD1564784; ZFY16_HUMAN; ZFYVE16; Zinc finger FYVE domain containing protein 16; Zinc finger FYVE domain-containing protein 16; Zinc finger, FYVE domain containing 16;

抗原和靶标

免疫原:
Uniprot:

Q7Z3T8(ZFY16_HUMAN) >>Visit HPA database.

基因/基因ID:
ZFYVE16(9765)
表达:
Q7Z3T8 ZFY16_HUMAN:

Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.

序列:
MDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQECVNSCASSETSYGTNESSLNEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTPCVSSTDHDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESIVDFNMSSALTRQSSKMFHAKDKLQHKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEGKTSALTCSLPKNEDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLDLKDNDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHEEIQNSVVLGGEPFKENDLLKQEKCKSILLQSLIEGMEDRKIDPDQTVIRAESLDGGDTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAELDAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSVGGARPKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSEGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYETISKAQAFERMMSPTGSNLKSNHSDECTTVQPPQENQTSSIPSPATLPVSALKQPGVEGLCSKEQKRVWFADGILPNGEVADTTKLSSGSKRCSEDFSPLSPDVPMTVNTVDHSHSTTVEKPNNETGDITRNEIIQSPISQVPSVEKLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSPTGVLVNSNLPIASISDYRLLCDINKYVCNKISLLPNDEDSLPPLLVASGEKGSVPVVEEHPSHEQIILLLEGESFHPVTFVLNANLLVNVKFIFYSSDKYWYFSTNGLHGLGQAEIIILLLCLPNEDTIPKDIFRLFITIYKDALKGKYIENLDNITFTESFLSSKDHGGFLFITPTFQKLDDLSLPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSIRGRKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLNSSNEHVISIGASFSTEADSHLVCIQNDGIYETQANSATGHPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQITPETMNGLRLALREQKDFKITCGKVDAVDLREYVDICWVDAEEKGNKGVISSVDGISLQGFPSEKIKLEADFETDEKIVKCTEVFYFLKDQDLSILSTSYQFAKEIAMACSAALCPHLKTLKSNGMNKIGLRVSIDTDMVEFQAGSEGQLLPQHYLNDLDSALIPVIHGGTSNSSLPLEIELVFFIIEHLF

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Bovine
92
Sheep
92
Horse
85
Dog
85
Chicken
83
Pig
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q7Z3T8 作为底物

Site PTM Type Enzyme
S10 Phosphorylation
Y28 Phosphorylation
Y36 Phosphorylation
Y73 Phosphorylation
K86 Ubiquitination
T89 Phosphorylation
S90 Phosphorylation
K95 Ubiquitination
Y118 Phosphorylation
K124 Ubiquitination
T140 Phosphorylation
S142 Phosphorylation
K148 Ubiquitination
S160 Phosphorylation
S167 Phosphorylation
S168 Phosphorylation
S170 Phosphorylation
K205 Ubiquitination
S216 Phosphorylation
S218 Phosphorylation
Y219 Phosphorylation
Y221 Phosphorylation
K228 Acetylation
K228 Ubiquitination
S253 Phosphorylation
K265 Ubiquitination
S305 Phosphorylation
S317 Phosphorylation
S319 Phosphorylation
K325 Ubiquitination
S330 Phosphorylation
K335 Ubiquitination
S348 Phosphorylation
S367 Phosphorylation
S376 Phosphorylation
S391 Phosphorylation
K392 Ubiquitination
S441 Phosphorylation
S446 Phosphorylation
K455 Ubiquitination
Y515 Phosphorylation
S529 Phosphorylation
Y541 Phosphorylation
K548 Ubiquitination
S549 Phosphorylation
S557 Phosphorylation
K558 Ubiquitination
Y578 Phosphorylation
K614 Ubiquitination
T616 Phosphorylation
K627 Ubiquitination
S635 Phosphorylation
S643 Phosphorylation
K650 Ubiquitination
S654 Phosphorylation
S661 Phosphorylation
K740 Ubiquitination
Y789 Phosphorylation
S815 Phosphorylation
S845 Phosphorylation
T848 Phosphorylation
K855 Ubiquitination
K865 Ubiquitination
S896 Phosphorylation
S903 Phosphorylation
T928 Phosphorylation
T932 Phosphorylation
S939 Phosphorylation
S942 Phosphorylation
S946 Phosphorylation
K1006 Ubiquitination
K1011 Ubiquitination
S1029 Phosphorylation
T1120 Phosphorylation
K1147 Ubiquitination
T1156 Phosphorylation
Y1201 Phosphorylation
K1202 Ubiquitination
Y1204 Phosphorylation
T1209 Phosphorylation
S1210 Phosphorylation
K1257 Ubiquitination
K1336 Ubiquitination
S1337 Phosphorylation
K1364 Ubiquitination
K1367 Ubiquitination
K1372 Ubiquitination
Y1381 Phosphorylation
K1392 Ubiquitination
K1395 Ubiquitination
K1413 Ubiquitination
K1452 Acetylation

研究背景

功能:

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.

细胞定位:

Cytoplasm. Early endosome membrane>Peripheral membrane protein.
Note: Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.

亚基结构:

Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2.

蛋白家族:

The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway.   (View pathway)

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