| 产品: | CAPG 抗体 |
| 货号: | AF0012 |
| 描述: | Rabbit polyclonal antibody to CAPG |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 39 kDa; 38kD(Calculated). |
| 蛋白号: | P40121 |
| RRID: | AB_2845471 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0012, RRID:AB_2845471.
展开/折叠
Actin capping protein GCAP39; Actin regulatory protein CAP G; Actin regulatory protein CAP-G; AFCP; Capg; CAPG_HUMAN; Capping actin protein gelsolin like; Capping protein (actin filament) gelsolin like; Capping protein gelsolin like; Epididymis secretory protein Li 66; gCap39; Gelsolin like capping protein; HEL S 66; Macrophage capping protein; Macrophage-capping protein; mbh1; MCP; Myc basic motif homolog 1;
抗原和靶标
- P40121 CAPG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDWK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P40121 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| Y2 | Phosphorylation | Uniprot | |
| T3 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| T128 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K137 | Acetylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| T212 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K231 | Acetylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| Y322 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot |
研究背景
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
The N-terminus is blocked.
Nucleus. Cytoplasm. Melanosome. Cell projection>Lamellipodium. Cell projection>Ruffle.
Note: In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia.
Macrophages and macrophage-like cells.
Interacts with NUP62. Interacts with NUTF2 and RAN; involved in CAPG nuclear import.
Belongs to the villin/gelsolin family.
限制条款
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