| 产品: | PLXA1 抗体 |
| 货号: | DF12510 |
| 描述: | Rabbit polyclonal antibody to PLXA1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Dog, Chicken, Xenopus |
| 分子量: | 211 kDa; 211kD(Calculated). |
| 蛋白号: | Q9UIW2 |
| RRID: | AB_2845472 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12510, RRID:AB_2845472.
展开/折叠
NOV; NOV/plexin A1 protein; NOVP; Plexin-A1; Plexin1; PlexinA1; PLXA1_HUMAN; PLXN1; Plxna1; PLXNA1 protein; Semaphorin receptor NOV;
抗原和靶标
- Q9UIW2 PLXA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKILVDLSNPGGRPALAYESVVAQEGSPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRRDACERADEPQRFAADLLQCVQLTVQPRNVSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTESESVLEDGRIHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNVADCAFLEGRVNVSEDCPQILPSTQIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLRHHCAADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVGGRPCSFSWRNSREIRCLTPPGQSPGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGIERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCTLTVSETQLLCEAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRPKAADMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDADVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYITKYKDEILAALEKDEQARRQRLRSKLEQVVDTMALSS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UIW2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| N77 | N-Glycosylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| T726 | O-Glycosylation | Uniprot | |
| K1041 | Ubiquitination | Uniprot | |
| N1043 | N-Glycosylation | Uniprot | |
| Y1097 | Phosphorylation | Uniprot | |
| Y1403 | Phosphorylation | Uniprot | |
| K1418 | Ubiquitination | Uniprot | |
| S1422 | Phosphorylation | Uniprot | |
| K1427 | Ubiquitination | Uniprot | |
| K1454 | Acetylation | Uniprot | |
| Y1486 | Phosphorylation | Uniprot | |
| K1492 | Ubiquitination | Uniprot | |
| Y1500 | Phosphorylation | Uniprot | |
| K1501 | Ubiquitination | Uniprot | |
| K1521 | Ubiquitination | Uniprot | |
| K1576 | Ubiquitination | Uniprot | |
| S1597 | Phosphorylation | Uniprot | |
| Y1608 | Phosphorylation | Uniprot | |
| T1615 | Phosphorylation | Uniprot | |
| K1618 | Ubiquitination | Uniprot | |
| S1619 | Phosphorylation | Uniprot | |
| S1621 | Phosphorylation | Uniprot | |
| Y1623 | Phosphorylation | Uniprot | |
| S1625 | Phosphorylation | Uniprot | |
| S1631 | Phosphorylation | Uniprot | |
| S1632 | Phosphorylation | Uniprot | |
| S1635 | Phosphorylation | Uniprot | |
| S1638 | Phosphorylation | Uniprot | |
| S1672 | Phosphorylation | Uniprot | |
| Y1679 | Phosphorylation | Uniprot | |
| K1687 | Ubiquitination | Uniprot | |
| K1793 | Ubiquitination | Uniprot | |
| K1799 | Ubiquitination | Uniprot | |
| K1804 | Ubiquitination | Uniprot | |
| Y1817 | Phosphorylation | Uniprot | |
| K1863 | Ubiquitination | Uniprot | |
| K1872 | Ubiquitination | Uniprot |
研究背景
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Cell membrane>Single-pass type I membrane protein.
Detected in fetal brain, lung, liver and kidney.
Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).
Belongs to the plexin family.
研究领域
· Organismal Systems > Development > Axon guidance. (View pathway)
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