| 产品: | DTX2 抗体 |
| 货号: | DF12526 |
| 描述: | Rabbit polyclonal antibody to DTX2 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 67 kDa; 67kD(Calculated). |
| 蛋白号: | Q86UW9 |
| RRID: | AB_2845488 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12526, RRID:AB_2845488.
展开/折叠
Deltex 2; deltex homolog 2 (Drosophila); deltex, Drosophila, homolog of, 2; Deltex2; DTX2; DTX2_HUMAN; hDTX2; Highly similar to hPMSR6 [H.sapiens]; KIAA1528; Probable E3 ubiquitin-protein ligase DTX2; Protein deltex 2; Protein deltex-2; RING finger protein 58; RNF58; Zinc ion binding protein;
抗原和靶标
- Q86UW9 DTX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGTHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTSPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q86UW9 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y75 | Phosphorylation | Uniprot | |
| T153 | Phosphorylation | Uniprot | |
| Y156 | Phosphorylation | Uniprot | |
| R213 | Methylation | Uniprot | |
| R215 | Methylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| R233 | Methylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| K249 | Acetylation | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| R256 | Methylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| R281 | Methylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| S373 | Phosphorylation | Uniprot | |
| K379 | Acetylation | Uniprot | |
| K383 | Acetylation | Uniprot | |
| T386 | Phosphorylation | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K553 | Acetylation | Uniprot | |
| K553 | Ubiquitination | Uniprot | |
| K557 | Acetylation | Uniprot |
研究背景
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Cytoplasm. Nucleus.
Note: Predominantly cytoplasmic. Partially nuclear.
Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Belongs to the Deltex family.
研究领域
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
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