| 产品: | ARPC1B 抗体 |
| 货号: | DF12560 |
| 描述: | Rabbit polyclonal antibody to ARPC1B |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 41 kDa; 41kD(Calculated). |
| 蛋白号: | O15143 |
| RRID: | AB_2845522 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12560, RRID:AB_2845522.
展开/折叠
Actin related protein 2/3 complex subunit 1B 41kDa; Actin related protein 2/3 complex subunit 1B; Actin-related protein 2/3 complex subunit 1B; ARC1B_HUMAN; ARC41; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; Arpc1b; p40 ARC; p41 ARC; p41-Arc;
抗原和靶标
- O15143 ARC1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O15143 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K18 | Acetylation | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| T21 | Phosphorylation | O14965 (AURKA) , Q13153 (PAK1) | Uniprot |
| Y35 | Phosphorylation | Uniprot | |
| K37 | Acetylation | Uniprot | |
| K41 | Acetylation | Uniprot | |
| K44 | Acetylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| Y77 | Phosphorylation | Uniprot | |
| K82 | Acetylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| T89 | Phosphorylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| Y172 | Phosphorylation | Uniprot | |
| K174 | Acetylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| T183 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| T315 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| K326 | Methylation | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| K367 | Ubiquitination | Uniprot |
研究背景
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Cytoplasm>Cytoskeleton. Nucleus.
Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
Belongs to the WD repeat ARPC1 family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.
· Human Diseases > Infectious diseases: Bacterial > Shigellosis.
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
限制条款
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