| 产品: | FATP4 抗体 |
| 货号: | DF12606 |
| 描述: | Rabbit polyclonal antibody to FATP4 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Zebrafish, Bovine, Horse, Rabbit, Dog, Xenopus |
| 分子量: | 70 kDa; 72kD(Calculated). |
| 蛋白号: | Q6P1M0 |
| RRID: | AB_2845568 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12606, RRID:AB_2845568.
展开/折叠
ACSVL 4; ACSVL4; EC 6.2.1; FATP 4; FATP4; Fatty acid transport protein 4; Fatty acid transport protein4; IPS; Long chain fatty acid transport protein 4; Long chain fatty acid transport protein4; OTTHUMP00000022264; S27A4; SLC27 A4; SLC27A 4; Solute carrier family 27 (fatty acid transporter) member 4; Solute carrier family 27 member 4; Solute carrier family 27 member4;
抗原和靶标
Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.
- Q6P1M0 S27A4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6P1M0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| T170 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| Y243 | Phosphorylation | Uniprot | |
| Y245 | Phosphorylation | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| Y264 | Phosphorylation | Uniprot | |
| S373 | Phosphorylation | Uniprot | |
| S411 | Phosphorylation | Uniprot | |
| T425 | Phosphorylation | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| Y463 | Phosphorylation | Uniprot | |
| K471 | Acetylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K475 | Ubiquitination | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| S555 | Phosphorylation | Uniprot | |
| K571 | Ubiquitination | Uniprot | |
| Y576 | Phosphorylation | Uniprot | |
| K595 | Ubiquitination | Uniprot | |
| K598 | Ubiquitination | Uniprot | |
| K603 | Ubiquitination | Uniprot | |
| K612 | Ubiquitination | Uniprot | |
| K622 | Ubiquitination | Uniprot | |
| K642 | Ubiquitination | Uniprot |
研究背景
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).
Membrane>Multi-pass membrane protein. Endoplasmic reticulum membrane.
Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.
Belongs to the ATP-dependent AMP-binding enzyme family.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Digestive system > Fat digestion and absorption.
限制条款
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