| 产品: | FLCN 抗体 |
| 货号: | DF12608 |
| 描述: | Rabbit polyclonal antibody to FLCN |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Bovine, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 45 kDa,70kDa; 64kD(Calculated). |
| 蛋白号: | Q8NFG4 |
| RRID: | AB_2845570 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12608, RRID:AB_2845570.
展开/折叠
BHD; BHD skin lesion fibrofolliculoma protein; Birt Hogg Dube syndrome protein; Birt-Hogg-Dube syndrome protein; DKFZp547A118; FLCL; Flcn; FLCN_HUMAN; FLJ45004; FLJ99377; Folliculin; MGC17998; MGC23445;
抗原和靶标
Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach.
- Q8NFG4 FLCN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGDGNEDSPGQGEQAEEEEGGIQMNSRMRAHSPAEGASVESSSPGPKKSDMCEGCRSLAAGHPGYISHDKETSIKYVSHQHPSHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIITIMMDRIYLINSWPFLLGKVRGIIDELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHTSFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPVLPESTEGRELTQGPAESSSLSGCGSWQPRKLPVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVDLVQSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPHVQIPPHVLSSEFAVIVEVHAAARSTLHPVGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKIEAALTNQNLSVDVVDQCLVCLKEEWMNKVKVLFKFTKVDSRPKEDTQKLLSILGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPTASESRN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8NFG4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S62 | Phosphorylation | P54646 (PRKAA2) | Uniprot |
| S68 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| T224 | Phosphorylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| R477 | Methylation | Uniprot | |
| K534 | Ubiquitination | Uniprot | |
| S537 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| K559 | Ubiquitination | Uniprot | |
| K562 | Ubiquitination | Uniprot | |
| S571 | Phosphorylation | Uniprot |
研究背景
May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.
Phosphorylated. Several different phosphorylated forms exist.
Cytoplasm. Nucleus.
Note: Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach.
Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase. Interacts with HSP90AA1 in the presence of FNIP1. Interacts with HSP70, STUB1, CDC37, AHSA1, CCT2, STIP1, PTGES3 and PPP5C.
Belongs to the folliculin family.
研究领域
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Human Diseases > Cancers: Specific types > Renal cell carcinoma. (View pathway)
限制条款
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