| 产品: | GALE 抗体 |
| 货号: | DF12611 |
| 描述: | Rabbit polyclonal antibody to GALE |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 38 kDa; 38kD(Calculated). |
| 蛋白号: | Q14376 |
| RRID: | AB_2845573 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12611, RRID:AB_2845573.
展开/折叠
FLJ95174; FLJ97302; Galactose 4 epimerase UDP; Galactowaldenase; galE; GALE_HUMAN; OTTHUMP00000002991; OTTHUMP00000002994; OTTHUMP00000037931; OTTHUMP00000044857; SDR1E1; short chain dehydrogenase/reductase family 1E member 1; UDP galactose 4 epimerase; UDP galactose 4' epimerase; UDP glucose 4 epimerase; UDP-galactose 4-epimerase; UDP-glucose 4-epimerase;
抗原和靶标
- Q14376 GALE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q14376 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S44 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| Y157 | Phosphorylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| T232 | Phosphorylation | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot |
研究背景
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Homodimer.
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
研究领域
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Carbohydrate metabolism > Amino sugar and nucleotide sugar metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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