产品: GSTA2 抗体
货号: DF12623
描述: Rabbit polyclonal antibody to GSTA2
应用: WB
反应: Human, Mouse, Rat
分子量: 26 kDa; 26kD(Calculated).
蛋白号: P09210
RRID: AB_2845585

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
GSTA2 Antibody detects endogenous levels of total GSTA2.
RRID:
AB_2845585
引用格式: Affinity Biosciences Cat# DF12623, RRID:AB_2845585.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EC 2.5.1.18; Glutathione S transferase 2; Glutathione S transferase A2; Glutathione S-alkyltransferase A2; Glutathione S-aralkyltransferase A2; Glutathione S-aryltransferase A2; Glutathione S-transferase alpha 2; Glutathione S-transferase GT41A; Glutathione S-transferase Ya-2; Glutathione S-transferase, alpha 2 (Yc2); GST 1b-1b; GST A2-2; GST class alpha member 2; GST gamma; GST HA subunit 2; GST Ya2; GST, class alpha, 2; GST2; Gst2-2; GSTA2 2; GSTA2-2; Gstc-2; Gstc2; GTA2; GTH2; HA subunit 2; Liver GST2; MGC10525; OTTHUMP00000017883; S-(hydroxyalkyl)glutathione lyase A2;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
序列:
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAKLALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF

翻译修饰 - P09210 作为底物

Site PTM Type Enzyme
Y9 Phosphorylation
S10 Phosphorylation
S37 Phosphorylation
Y49 Phosphorylation
Y74 Phosphorylation
S77 Phosphorylation
Y79 Phosphorylation
Y82 Phosphorylation
K84 Acetylation
Y132 Phosphorylation
S142 Phosphorylation
Y147 Phosphorylation
K152 Acetylation
S154 Phosphorylation
S176 Phosphorylation
S177 Phosphorylation
S189 Phosphorylation
T193 Phosphorylation
K195 Acetylation
K196 Acetylation
S202 Phosphorylation
S212 Phosphorylation

研究背景

功能:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Liver.

亚基结构:

Homodimer or heterodimer of GSTA1 and GSTA2.

蛋白家族:

Belongs to the GST superfamily. Alpha family.

研究领域

· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Chemical carcinogenesis.

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

· Metabolism > Metabolism of other amino acids > Glutathione metabolism.

· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.

文献引用

1). Transcriptomics and metabolomics reveal the role of CYP1A2 in psoralen/isopsoralen-induced metabolic activation and hepatotoxicity. Phytotherapy Research, 2023 (PubMed: 36056681) [IF=7.2]

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