| 产品: | GSTO1 抗体 |
| 货号: | DF12626 |
| 描述: | Rabbit polyclonal antibody to GSTO1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Dog, Chicken |
| 分子量: | 30 kDa; 28kD(Calculated). |
| 蛋白号: | P78417 |
| RRID: | AB_2845588 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12626, RRID:AB_2845588.
展开/折叠
AA407097; AI194287; AU018802; DKFZp686H13163; EC 2.5.1.18; Glutathione S transferase omega 1; Glutathione S-transferase omega 1-1; Glutathione S-transferase omega; Glutathione S-transferase omega-1; Glutathione transferase omega 1; Glutathione-dependent dehydroascorbate reductase; Glutathione-S-transferase like; Glutathione-S-transferase omega 1; GSTO 1-1; GSTO-1; GSTO1 1; Gsto1; GSTO1_HUMAN; GSTTLp28; GSTX; Gtsttl; MGC94845; MMA(V) reductase; Monomethylarsonic acid reductase; OTTHUMP00000020429; p28; S-(Phenacyl)glutathione reductase; SPG-R;
抗原和靶标
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
- P78417 GSTO1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYGL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P78417 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| S13 | O-Glycosylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| R30 | Methylation | Uniprot | |
| K57 | Acetylation | Uniprot | |
| K57 | Sumoylation | Uniprot | |
| K59 | Acetylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K65 | Acetylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| K122 | Acetylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| K143 | Acetylation | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| K148 | Acetylation | Uniprot | |
| K152 | Acetylation | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| K160 | Acetylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K161 | Acetylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| T217 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| Y239 | Phosphorylation | Uniprot |
研究背景
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Cytoplasm>Cytosol.
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
Homodimer.
Belongs to the GST superfamily. Omega family.
研究领域
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
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