产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12642, RRID:AB_2845604.
展开/折叠
IMDH1_HUMAN; IMP (inosine monophosphate) dehydrogenase 1; IMP dehydrogenase 1; IMPD 1; IMPD; IMPD1; IMPDH 1; IMPDH I; IMPDH-I; Impdh1; Inosine 5' monophosphate dehydrogenase 1; Inosine monophosphate dehydrogenase 1; Inosine-5''-monophosphate dehydrogenase 1; LCA11; RP10; sWSS2608;
抗原和靶标
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
- P20839 IMDH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P20839 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K109 | Ubiquitination | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| R203 | Methylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| R231 | Methylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| K242 | Acetylation | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| R322 | Methylation | Uniprot | |
| Y400 | Phosphorylation | Uniprot | |
| K410 | Ubiquitination | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| K428 | Ubiquitination | Uniprot | |
| Y430 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| K436 | Acetylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| K450 | Ubiquitination | Uniprot |
研究背景
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Cytoplasm. Nucleus.
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Homotetramer.
Belongs to the IMPDH/GMPR family.
研究领域
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
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