| 产品: | OSMR 抗体 |
| 货号: | DF12682 |
| 描述: | Rabbit polyclonal antibody to OSMR |
| 应用: | WB |
| 反应: | Human, Mouse, Monkey |
| 预测: | Pig, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 111 kDa; 111kD(Calculated). |
| 蛋白号: | Q99650 |
| RRID: | AB_2845644 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12682, RRID:AB_2845644.
展开/折叠
IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta; MGC140467; MGC150626; MGC150627; MGC75127; Oncostatin M receptor; Oncostatin M specific receptor subunit beta; Oncostatin M-specific receptor, beta; Oncostatin-M-specific receptor subunit beta; Osmr; OSMR_HUMAN; OSMRB;
抗原和靶标
Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038).
- Q99650 OSMR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLLDPGEHYC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q99650 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T33 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| Y389 | Phosphorylation | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| K677 | Ubiquitination | Uniprot | |
| K688 | Ubiquitination | Uniprot | |
| Y689 | Phosphorylation | Uniprot | |
| K767 | Ubiquitination | Uniprot | |
| K779 | Ubiquitination | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| K787 | Ubiquitination | Uniprot | |
| K789 | Ubiquitination | Uniprot | |
| S800 | Phosphorylation | Uniprot | |
| K812 | Ubiquitination | Uniprot | |
| K817 | Ubiquitination | Uniprot | |
| K825 | Ubiquitination | Uniprot | |
| S826 | Phosphorylation | Uniprot | |
| T828 | Phosphorylation | Uniprot | |
| T830 | Phosphorylation | Uniprot | |
| K834 | Ubiquitination | Uniprot | |
| Y837 | Phosphorylation | Uniprot | |
| Y839 | Phosphorylation | Uniprot | |
| K845 | Ubiquitination | Uniprot | |
| T860 | Phosphorylation | Uniprot | |
| Y861 | Phosphorylation | Uniprot | |
| S877 | Phosphorylation | Uniprot | |
| K879 | Ubiquitination | Uniprot | |
| S889 | Phosphorylation | Uniprot | |
| K895 | Ubiquitination | Uniprot | |
| K899 | Ubiquitination | Uniprot | |
| Y901 | Phosphorylation | Uniprot | |
| Y917 | Phosphorylation | Uniprot | |
| K929 | Ubiquitination | Uniprot | |
| Y945 | Phosphorylation | Uniprot | |
| Y978 | Phosphorylation | Uniprot |
研究背景
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Membrane>Single-pass type I membrane protein.
Expressed in keratinocytes (at protein level). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells.
Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 2 subfamily.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
限制条款
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