| 产品: | PIP5K1B 抗体 |
| 货号: | DF12698 |
| 描述: | Rabbit polyclonal antibody to PIP5K1B |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 62 kDa; 61kD(Calculated). |
| 蛋白号: | O14986 |
| RRID: | AB_2845659 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12698, RRID:AB_2845659.
展开/折叠
MSS 4; MSS4; Phosphatidylinositol 4 phosphate 5 kinase type 1 beta; Phosphatidylinositol-4-phosphate 5-kinase type I beta; Phosphatidylinositol-4-phosphate 5-kinase type-1 beta; PI4P5K 1 beta; PI51B_HUMAN; PIP5K1-beta; PIP5K1B; PIP5KIbeta; Pipk 5 beta; Pipk 5b; Protein STM 7; Protein STM-7; PtdIns(4)P-5-kinase 1 beta; STM 7; STM7; STM7 LSB; Type I phosphatidylinositol 4 phosphate 5 kinase beta; Type I phosphatidylinositol-4-phosphate 5-kinase beta;
抗原和靶标
- O14986 PI51B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O14986 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| Y105 | Phosphorylation | P43405 (SYK) | Uniprot |
| K143 | Ubiquitination | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K301 | Methylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S421 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot |
研究背景
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
Endomembrane system.
Note: Associated with membranes.
Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.
Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
限制条款
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