| 产品: | PPARGC1B 抗体 |
| 货号: | DF12703 |
| 描述: | Rabbit polyclonal antibody to PPARGC1B |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 110 kDa; 113kD(Calculated). |
| 蛋白号: | Q86YN6 |
| RRID: | AB_2845664 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12703, RRID:AB_2845664.
展开/折叠
Peroxisome proliferator-activated receptor gamma coactivator 1-beta;PGC-1-beta;PPAR-gamma coactivator 1-beta;PPARGC-1-beta;PGC-1-related estrogen receptor alpha coactivator;PERC;PGC1;PGC1B;PPARGC1;
抗原和靶标
- Q86YN6 PRGC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q86YN6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S239 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| K357 | Ubiquitination | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S638 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| T647 | Phosphorylation | Uniprot | |
| S711 | Phosphorylation | Uniprot | |
| S854 | Phosphorylation | Uniprot | |
| S856 | Phosphorylation | Uniprot | |
| S859 | Phosphorylation | Uniprot | |
| S865 | Phosphorylation | Uniprot | |
| Y943 | Phosphorylation | Uniprot | |
| T947 | Phosphorylation | Uniprot | |
| Y948 | Phosphorylation | Uniprot | |
| Y987 | Phosphorylation | Uniprot | |
| Y990 | Phosphorylation | Uniprot | |
| S992 | Phosphorylation | Uniprot |
研究背景
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Nucleus.
Ubiquitous with higher expression in heart, brain and skeletal muscle.
Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.
Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
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