| 产品: | PTGES2 抗体 |
| 货号: | DF12712 |
| 描述: | Rabbit polyclonal antibody to PTGES2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Dog |
| 分子量: | 30 kDa; 42kD(Calculated). |
| 蛋白号: | Q9H7Z7 |
| RRID: | AB_2845673 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12712, RRID:AB_2845673.
展开/折叠
C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PTGES2;
抗原和靶标
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
- Q9H7Z7 PGES2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H7Z7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| K53 | Acetylation | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| Y209 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| Y287 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| Y308 | Phosphorylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| T371 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot |
研究背景
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).
Golgi apparatus membrane>Single-pass membrane protein.
Cytoplasm>Perinuclear region.
Note: Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10.
Belongs to the GST superfamily.
研究领域
· Metabolism > Lipid metabolism > Arachidonic acid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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