| 产品: | SDHB 抗体 |
| 货号: | DF12732 |
| 描述: | Rabbit polyclonal antibody to SDHB |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 32 kDa; 32kD(Calculated). |
| 蛋白号: | P21912 |
| RRID: | AB_2845693 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12732, RRID:AB_2845693.
展开/折叠
CWS2; DHSB_HUMAN; FLJ92337; Ip; Iron sulfur subunit; Iron sulfur subunit of complex II; Iron-sulfur subunit of complex II; mitochondrial; PGL 4; PGL4; SDH 1; SDH; SDH1; SDH2; SDH2, homolog of; SdhB; SDHIP; Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial; Succinate dehydrogenase [ubiquinone] iron sulfur subunit; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Succinate Dehydrogenase 1 Iron Sulfur Subunit; Succinate Dehydrogenase 2, S. cerevisiae, homolog of; Succinate dehydrogenase complex iron sulfur subunit B; Succinate dehydrogenase complex subunit B iron sulfur; Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein; succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Succinate dehydrogenase iron sulfur protein;
抗原和靶标
- P21912 SDHB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P21912 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K41 | Acetylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| C93 | S-Nitrosylation | Uniprot | |
| C98 | S-Nitrosylation | Uniprot | |
| C101 | S-Nitrosylation | Uniprot | |
| C113 | S-Nitrosylation | Uniprot | |
| T119 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| S222 | Phosphorylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot |
研究背景
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Mitochondrion inner membrane>Peripheral membrane protein>Matrix side.
Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB.
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Carbohydrate metabolism > Citrate cycle (TCA cycle).
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
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