| 产品: | SESN3 抗体 |
| 货号: | DF12735 |
| 描述: | Rabbit polyclonal antibody to SESN3 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 57 kDa; 57kD(Calculated). |
| 蛋白号: | P58005 |
| RRID: | AB_2845696 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12735, RRID:AB_2845696.
展开/折叠
MGC29667; OTTHUMP00000236979; OTTHUMP00000236986; SESN3; SESN3_HUMAN; SEST3; Sestrin 3; Sestrin-3;
抗原和靶标
- P58005 SESN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P58005 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R3 | Methylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| R98 | Methylation | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| T288 | Phosphorylation | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| Y455 | Phosphorylation | Uniprot |
研究背景
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
Cytoplasm.
Widely expressed.
Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by leucine. Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them. Interacts with the TORC2 complex; through RICTOR (By similarity).
The C-terminal domain may mediate interaction with GATOR2 and regulation of TORC1 signaling.
Belongs to the sestrin family.
研究领域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
限制条款
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