| 产品: | Syntaxin4 抗体 |
| 货号: | DF12761 |
| 描述: | Rabbit polyclonal antibody to Syntaxin4 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 35 kDa, 40 kDa; 34kD(Calculated). |
| 蛋白号: | Q12846 |
| RRID: | AB_2845722 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12761, RRID:AB_2845722.
展开/折叠
NY REN 31 antigen; p35 2; PLACENTAL; Renal carcinoma antigen NY REN 31; Renal carcinoma antigen NY-REN-31; Stx4; STX4_HUMAN; STX4A; Syntaxin 4; syntaxin 4A (placental); Syntaxin 4A; Syntaxin-4;
抗原和靶标
Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.
- Q12846 STX4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q12846 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| S14 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| T31 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| T51 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| T72 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T120 | Phosphorylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| T125 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| S248 | Phosphorylation | Uniprot | |
| Y251 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot |
研究背景
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
Cell membrane>Single-pass type IV membrane protein.
Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.
Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity). Interacts with STXBP5L (By similarity).
Belongs to the syntaxin family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
限制条款
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