| 产品: | TRAF5 抗体 |
| 货号: | DF12779 |
| 描述: | Rabbit polyclonal antibody to TRAF5 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 55 kDa; 64kD(Calculated). |
| 蛋白号: | O00463 |
| RRID: | AB_2845740 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12779, RRID:AB_2845740.
展开/折叠
MGC:39780; RING finger protein 84; RNF 84; RNF84; TNF receptor associated factor 5; TNF receptor-associated factor 5; TRAF 5; Traf5; TRAF5_HUMAN;
抗原和靶标
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
- O00463 TRAF5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O00463 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Ubiquitination | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| C161 | S-Nitrosylation | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| K493 | Ubiquitination | Uniprot | |
| K500 | Ubiquitination | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| K534 | Ubiquitination | Uniprot | |
| K539 | Ubiquitination | Uniprot |
研究背景
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Cytoplasm. Cytoplasm>Cytosol.
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Belongs to the TNF receptor-associated factor family. A subfamily.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Human Diseases > Cancers: Specific types > Small cell lung cancer. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
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